Five year follow-up of coronary sinus delivery of bone marrow cells for congestive heart failure

Introducción Background: Randomized studies suggest that intracoronary infusion of autologous cells improve heart function for patients with heart failure (HF). However, results have been mixed due to high cell loss and poor delivery. Coronary sinus delivery (CSD) of bone marrow cells holds promise for patients with HF. Methods: 77 patients were enrolled and completed 5 years follow up. […]

Safety and feasibility of percutaneous retrograde coronary sinus delivery of autologous bone marrow mononuclear cell transplantation in patients with chronic refractory angina – Jorge Tuma

Introducción Background: Chronic refractory angina is a challenging clinical problem with limited treatment options. The results of early cardiovascular stem cell trials using ABMMC have been promising but have utilized intracoronary or intramyocardial delivery. The goal of the study was to evaluate the safety and early efficacy of autologous bone marrow derived mononuclear cells (ABMMC) delivered […]

Heart Failure Improvement after Autologous Bone Marrow Mononuclear Cells (ABMMC) Transplantation

Introducción Background: Pilot studies suggest that intracoronary transplantation of unselected ABMMC cells may improve Left Ventricular Ejection Fraction (LVEF) in heart failure (HF) patients. Methods: Eighteen patients were enrolled and completed 1 year follow up. Patients underwent SPECT evaluation, all had ejection fraction < 35%, 6 patients were randomly allocated to the control group and 12 in Bone […]