RESCUE-HF Trial: Retrograde Delivery of Allogeneic Umbilical Cord Lining Subepithelial Cells in Patients With Heart Failure

Introducción Cell therapy is an evolving option for patients with end-stage heart failure. First-generation cell therapy trials have had marginal success. Our goal was to evaluate retrograde delivery of allogeneic umbilical cord subepithelial cells (UCSECs) in patients with heart failure. A prospective open-label dose escalation study of the safety and feasibility of UCSECs infused retrogradely […]

RESCUE-HF Trial: Retrograde Delivery of Allogeneic Umbilical CordLining Subepithelial Cells in Patients With Heart Failure – Jorge Tuma

Introducción The overall patient mortality from coronary artery disease (CAD) has declined because of several factors including improvements in pharmacologic therapy and revascularization techniques1. However, cardiovascular disease still remains the leading cause of death in the world2. The life-saving advances in management of acute and chronic CAD have been associated with an increased prevalence of […]

Safety and feasibility of percutaneous retrogradecoronary sinus delivery of autologous bonemarrow mononuclear cell transplantation inpatients with chronic refractory angina – Jorge Tuma

Introducción Background: Chronic refractory angina is a challenging clinical problem with limited treatment options. The results of early cardiovascular stem cell trials using ABMMC have been promising but have utilized intracoronary or intramyocardial delivery. The goal of the study was to evaluate the safety and early efficacy of autologous bone marrow derived mononuclear cells (ABMMC) […]

AUTOLOGOUS BONE MARROW MONONUCLEAR CELL (ABMMC)TRANSPLANTATIONIN TYPE 1 AND TYPE 2 INSULIN DEPENDENT DIABETES MELLITUS (IDM) – Jorge Tuma

Introducción From June 2005 to January 2007, 28 consecutive patients: 8 Type 1 IDM (T1DM) and 20 type 2 IDM (T2IDM); who were receiving maximal medical therapy including insulin treatment for. Median time of disease for T2IDM patients was 13 years, without presence of pancreatic islet autoantibodies. After IRB approval and signed informed consent, bone […]

Redosing strategies for mesenchymal stem cell therapy for chronic obstructive pulmonary disease – Jorge Tuma

Introducción hronic obstructive pulmonary disease is both an obstructive and inflammatory disease. Mesenchymal stem cell (MSC) therapy has shown early promise to modulate inflammation and improve lung function. The therapy has limitations resulting from cell loss and sub-optimal delivery. Even when MSC therapy demonstrates a clinical benefit, there are questions related to redosing if the […]